5-Fluorouracil

Generic name: 5-Fluorouracil

Possible Side Effects

Nausea
Vomiting
Diarrhea
Mucositis or mouth ulcers
Fatigue or weakness
Hair loss (alopecia)
Low blood cell counts (anemia, leukopenia, thrombocytopenia) with higher infection risk
Hand-foot syndrome (reddening, swelling, and pain on palms or soles)
If you experience serious side effects, discuss with your doctor immediately. In India, contact your oncologist or go to the nearest government hospital or cancer centre for urgent advice.

Warnings / Contraindications

5-Fluorouracil (5-FU) may be unsafe in people allergic to it or other fluoropyrimidines.
Not recommended during pregnancy or breastfeeding; use effective contraception and consult your obstetrician/oncologist.
Caution in severe bone marrow suppression, active infections, or significant liver or kidney disease; may require avoidance or dose adjustments.
DPD deficiency increases the risk of serious toxicity; discuss family history or prior reactions with your doctor.
Interactions with other chemotherapy, radiation, or medicines that affect blood counts; inform your doctor and pharmacist of all medicines and supplements.
Topical 5-FU can cause severe local skin reactions; avoid broken skin and areas around eyes or mucous membranes; protect from sun.
Always check with a qualified doctor or pharmacist in India before starting, stopping, or changing any 5-FU treatment.