6-Mercaptopurine
Generic name: 6-Mercaptopurine
Possible Side Effects
Common side effects of 6-mercaptopurine include bone marrow suppression leading to low white blood cells and anemia, increasing infection risk.
Nausea, vomiting, loss of appetite, stomach pain or diarrhea are also commonly reported.
Liver-related side effects such as elevated liver enzymes, hepatitis, or jaundice can occur; regular liver function tests are often monitored in India.
Pancreatitis is a less common but important risk; sudden severe abdominal pain may occur.
Fatigue, weakness, and fever may accompany these effects.
Skin rashes, mouth ulcers, or hair thinning can occur in some people.
Because 6-mercaptopurine suppresses the immune system, there is an increased risk of infections; watch for signs of infection.
If you notice any serious side effects such as severe fever, unusual bleeding, severe abdominal pain, yellowing of the skin or eyes, or trouble breathing, discuss with a doctor immediately; always consult a qualified doctor or local healthcare provider in India for personal medical decisions.
Warnings / Contraindications
Do not use 6-mercaptopurine if you have an allergy to it or to related medicines such as azathioprine.
It can cause bone marrow suppression, leading to very low blood counts; watch for unusual bleeding, fever, infections, or extreme fatigue.
It may worsen liver disease and can cause pancreatitis; alert your doctor if you notice yellowing of skin/eyes, dark urine, upper abdominal pain, or persistent vomiting.
It can interact with medicines like allopurinol (and other xanthine oxidase inhibitors), certain antibiotics, and other immunosuppressants; tell your doctor about all medicines you take.
Genetic factors (low TPMT or NUDT15 activity) can raise the risk of serious side effects; your clinician may test before or during therapy.
Pregnancy and breastfeeding require careful consideration; consult a specialist before use.
In India, this medicine is used under medical supervision and requires regular blood tests at primary health centres, district or government hospitals; never start or stop on your own—please check with a doctor or pharmacist in India.